Discovery of Novel, Microbial Antigens Recognised by Mucosal Associated Invariant T Cells

Grant number: 1157388 | Funding period: 2019 - 2022

Completed

Abstract

Mucosal Associated Invariant T (MAIT) cells are an abundant yet poorly studied type of T cells in humans. Based on our discovery that MAIT cells target pathogens by recognising a by-product of their metabolism, this proposal will identify novel microbial metabolite targets of MAIT cells and provide new insights and approaches to anti-microbial immunity. Thereby this project will deepen our understanding of the biology of MAIT cells and could furnish novel agents to treat microbial infections.

Related publications (4)

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The role of mucosal-associated invariant T cells in visceral leishmaniasis

MDL Moreira, LO Borges-Fernandes, MA Pascoal-Xavier, ÁL Ribeiro, VHS Pereira, T Pediongco, MSDS Araújo, A Teixeira-Carvalho, AL de Carvalho, MVA Mourão, FA Campos, M Borges, M Carneiro, Z Chen, E Saunders, M McConville, M Tsuji, J McCluskey, OA Martins-Filho, SBG Eckle

2022-09-15

Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections...

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CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells

Michael NT Souter, Wael Awad, Shihan Li, Troi Pediongco, Bronwyn S Meehan, Lucy J Meehan, Zehua Tian, Zhe Zhao, Huimeng Wang, Adam Nelson, Jérôme Le Nours, Yogesh Khandokar, T Praveena, Jacinta Wubben, Jie Lin, Lucy C Sullivan, George Lovrecz, Jeffrey YW Mak, Ligong Liu, Lyudmila Kostenko

2022-01-01

Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of riboflavin-based antigens presented by t..

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Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections

MD Edmans, TK Connelley, S Jayaraman, C Vrettou, M Vordermeier, JYW Mak, L Liu, DP Fairlie, EA Maze, T Chrun, P Klenerman, SBG Eckle, E Tchilian, L Benedictus

2021-03-11

Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells that utilize a semi-invariant T cell receptor ..

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Biased MAIT TCR Usage Poised for Limited Antigen Diversity?

MNT Souter, SBG Eckle

2020-08-18

Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize the evolutionarily conserved maj..

University of Melbourne Researchers